WHO Arbovirus guideline: minimally important difference survey

WHO is seeking to refine our understanding of minimally important differences (MID) for arbovirus, particularly two outcomes: 1) major bleeding and 2) organ failure. Minimally important differences are the smallest changes in outcomes or measurements that are considered significant enough by patients to indicate a noticeable improvement or worsening of a condition.

Participants

WHO Arbovirus guideline – Minimally Important Difference survey1
18 responses from 19 participants invited.1
First name Last name email Completed Date submitted
Ismael Diallo  illah_diallo@hotmail.com Yes 2024-04-09
Mikaila Kabore  mikailakab@gmail.com Yes 2024-04-08
Carlos Pardo-Villamizar cpardov1@jhmi.edu Yes 2024-04-08
Orlando Cuellar   orlando_cuellar@hotmail.com Yes 2024-04-09
Kleber Giovanni Luz klebergluz@gmail.com Yes 2024-04-12
Erin Staples  auv1@cdc.gov Yes 2024-04-08
Taj Eldin Mohammedein  tajeldinmm@yahoo.com Yes 2024-04-12
Mostafa Salehi Vaziri  mostafavaziri1985@gmail.com Yes 2024-04-08
Cristina Domingo  Domingo-CarrascoC@rki.de Yes 2024-04-08
Michel Van Herp michel.van.herp@brussels.msf.org Yes 2024-04-05
Marta Lado Castro-Rial mlado@pih.org Yes 2024-04-01
Ashutosh Biswas asuaiims@gmail.com No –
Pisake Lumbiganon  pisake@kku.ac.th Yes 2024-04-05
P.S Indu  indupsaniltv@gmail.com Yes 2024-04-08
Lucy Lum Chai See  lumcs@ummc.edu.my Yes 2024-04-09
Leo Yee Sin  yee_sin_leo@ncid.sg Yes 2024-04-04
Ma. Esterlita V. Uy mvuy1@up.edu.ph Yes 2024-04-04
Emilie Javelle emilie.javelle@gmail.com Yes 2024-04-01
Liya Wassie liya.wassie@ahri.gov.et Yes 2024-04-15
1 As of 17 Apr 2024

Results

Major bleeding

Organ failure

Table overview

Major bleeding

WHO Clinical Management of Arbovirus guideline - Minimally Important Difference survey
Major Bleeding - As of 17 Apr 20241
Responses Total responses n Percentage
What percentage of people would consider a reduction in major bleeding of 1 per 1000 (i.e. 0.1%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 7 38.89%
Most (75- 90%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 1 5.56%
Most (75-90%) would consider this an unimportant or trivial reduction 18 2 11.11%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 6 33.33%
What percentage of people would consider a reduction in major bleeding of 5 per 1000 (i.e. 0.5%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 7 38.89%
Most (75- 90%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 4 22.22%
Most (75-90%) would consider this an unimportant or trivial reduction 18 4 22.22%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 1 5.56%
What percentage of people would consider a reduction in major bleeding of 10 per 1000 (i.e. 1%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 7 38.89%
Most (75- 90%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an important reduction 18 2 11.11%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 4 22.22%
Most (75-90%) would consider this an unimportant or trivial reduction 18 3 16.67%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 1 5.56%
What percentage of people would consider a reduction in major bleeding of 20 per 1000 (i.e. 2%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 9 50.00%
Majority (51-74%) would consider this an important reduction 18 4 22.22%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 3 16.67%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 2 11.11%
What percentage of people would consider a reduction in major bleeding of 30 per 1000 (i.e. 3%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 9 50.00%
Most (75- 90%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an important reduction 18 4 22.22%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 2 11.11%
Most (75-90%) would consider this an unimportant or trivial reduction 18 1 5.56%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 1 5.56%
What percentage of people would consider a reduction in major bleeding of 40 per 1000 (i.e. 4%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 9 50.00%
Most (75- 90%) would consider this an important reduction 18 2 11.11%
Majority (51-74%) would consider this an important reduction 18 3 16.67%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 2 11.11%
Most (75-90%) would consider this an unimportant or trivial reduction 18 1 5.56%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 1 5.56%
What percentage of people would consider a reduction in major bleeding of 50 per 1000 (i.e. 5%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 10 55.56%
Most (75- 90%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an important reduction 18 4 22.22%
Most (75-90%) would consider this an unimportant or trivial reduction 18 2 11.11%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 1 5.56%
What percentage of people would consider a reduction in major bleeding of 100 per 1000 (i.e. 10%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 10 55.56%
Most (75- 90%) would consider this an important reduction 18 3 16.67%
Majority (51-74%) would consider this an important reduction 18 3 16.67%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 1 5.56%
Most (75-90%) would consider this an unimportant or trivial reduction 18 1 5.56%
What percentage of people would consider a reduction in major bleeding of 150 per 1000 (i.e. 15%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 12 66.67%
Most (75- 90%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an important reduction 18 3 16.67%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 1 5.56%
Most (75-90%) would consider this an unimportant or trivial reduction 18 1 5.56%
What percentage of people would consider a reduction in major bleeding of 200 per 1000 (i.e. 20%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 14 77.78%
Most (75- 90%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an important reduction 18 2 11.11%
Most (75-90%) would consider this an unimportant or trivial reduction 18 1 5.56%
1 Results from 18 participants who completed the survey

You can download all responses here:

Organ failure

WHO Clinical Management of Arbovirus guideline - Minimally Important Difference survey
Organ failure - As of 17 Apr 20241
Responses Total responses n Percentage
What percentage of people would consider a reduction in organ failure of 1 per 1000 (i.e. 0.1%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 6 33.33%
Most (75- 90%) would consider this an important reduction 18 2 11.11%
Majority (51-74%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 2 11.11%
Most (75-90%) would consider this an unimportant or trivial reduction 18 1 5.56%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 6 33.33%
What percentage of people would consider a reduction in organ failure of 5 per 1000 (i.e. 0.5%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 6 33.33%
Most (75- 90%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an important reduction 18 2 11.11%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 2 11.11%
Most (75-90%) would consider this an unimportant or trivial reduction 18 4 22.22%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 3 16.67%
What percentage of people would consider a reduction in organ failure of 10 per 1000 (i.e. 1%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 7 38.89%
Most (75- 90%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an important reduction 18 2 11.11%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 3 16.67%
Most (75-90%) would consider this an unimportant or trivial reduction 18 3 16.67%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 2 11.11%
What percentage of people would consider a reduction in organ failure of 20 per 1000 (i.e. 2%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 7 38.89%
Most (75- 90%) would consider this an important reduction 18 2 11.11%
Majority (51-74%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 4 22.22%
Most (75-90%) would consider this an unimportant or trivial reduction 18 1 5.56%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 3 16.67%
What percentage of people would consider a reduction in organ failure of 30 per 1000 (i.e. 3%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 7 38.89%
Most (75- 90%) would consider this an important reduction 18 2 11.11%
Majority (51-74%) would consider this an important reduction 18 1 5.56%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 5 27.78%
Most (75-90%) would consider this an unimportant or trivial reduction 18 1 5.56%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 2 11.11%
What percentage of people would consider a reduction in organ failure of 40 per 1000 (i.e. 4%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 7 38.89%
Most (75- 90%) would consider this an important reduction 18 2 11.11%
Majority (51-74%) would consider this an important reduction 18 3 16.67%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 2 11.11%
Most (75-90%) would consider this an unimportant or trivial reduction 18 2 11.11%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 2 11.11%
What percentage of people would consider a reduction in organ failure of 50 per 1000 (i.e. 5%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 7 38.89%
Most (75- 90%) would consider this an important reduction 18 2 11.11%
Majority (51-74%) would consider this an important reduction 18 5 27.78%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 1 5.56%
Most (75-90%) would consider this an unimportant or trivial reduction 18 1 5.56%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 2 11.11%
What percentage of people would consider a reduction in organ failure of 100 per 1000 (i.e. 10%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 9 50.00%
Most (75- 90%) would consider this an important reduction 18 3 16.67%
Majority (51-74%) would consider this an important reduction 18 4 22.22%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 2 11.11%
What percentage of people would consider a reduction in organ failure of 150 per 1000 (i.e. 15%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 7 38.89%
Most (75- 90%) would consider this an important reduction 18 6 33.33%
Majority (51-74%) would consider this an important reduction 18 3 16.67%
Majority (51-74%) would consider this an unimportant or trivial reduction 18 1 5.56%
All or almost all (over 90%) would consider this an unimportant or trivial reduction 18 1 5.56%
What percentage of people would consider a reduction in organ failure of 200 per 1000 (i.e. 20%) important? (n=18)
All or almost all (over 90%) would consider this an important reduction 18 11 61.11%
Most (75- 90%) would consider this an important reduction 18 4 22.22%
Majority (51-74%) would consider this an important reduction 18 2 11.11%
Most (75-90%) would consider this an unimportant or trivial reduction 18 1 5.56%
1 Results from 18 participants who completed the survey

You can download all responses here: